Stress-Related Disorders can include a wide variety of conditions. Increasingly it is recognized that severe stress can take not only an emotional toll but also contribute to physical maladies. Stress can trigger an underlying condition, such as Major Depression, Bipolar Disorder, or Panic Attacks, or cause a reaction solely related to the stress, which is termed Adjustment Disorder and is sometimes called a Situational Depression. Intense Stress needs to be addressed because it can trigger a number of unhealthy responses in the body, such as the constant activation of the fight-or-flight reaction, excess cortisol secretion, sleep disturbance which in turn causes a number of unhealthy changes, a weakened immune system, and possibly lower levels of healthy chemicals in the brain, such as nerve growth factors. Intense, stress can also lead to Post-Traumatic Stress Disorder.